Abbreviations 3-MA: 3-Methyladenine ADSC: Adipose-derived stem cell DEG: Differentially expressed gene ROS: Reactive oxygen species LPOs: Lipid peroxides OGD: Oxygen and glucose deprivation MDA: Malondialdehyde SOD: Superoxide dismutase Fer-1: Ferrostatin-1 GSH: Glutathione H&E: Hematoxylin and eosin KEGG: Kyoto Encyclopedia of Genes and Genomes MRI: Magnetic resonance imaging NAC: N -Acetylcysteine Nec-1: Necrostatin-1 NS: Normal saline PBS: Phosphate-buffered saline qRT-PCR: Quantitative real-time polymerase chain reaction SD: Standard deviation TEM: Transmission electron microscopy References Smith P, Adams WP Jr, Lipschitz AH, Chau B, Sorokin E, Rohrich RJ, Brown SA
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Two rashers of raw bacon, a box of syringes and a vial of yellow liquid have been neatly arranged on a kitchen table
NCT02305381
Proc Natl Acad Sci USA 116(11):51085117
Average responders (~60% of patients): Weight loss of 23 kg over 6 months, plateauing thereafter
