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In its ground state, oxygen appears as a triplet ( 3 O 2 ), with two unpaired electrons (biradical) of parallel spins in two separate orbitals, which makes it paramagnetic and thus shows no affinity for organic molecules unless activated

However, TGF- signaling can suppress AhR expression via methyl-CpG-binding domain 2 (MBD2) -mediated promoter methylation, potentially limiting the antifibrotic efficacy of Kyn [117]

Its approval for obesity treatment has broadened its market appeal, especially as global obesity rates rise