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An increase in the total GSH level was correlated with enhanced GR activity

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To understand the role of lipids as triggers of A aggregation, one could start from the observation that this process involves a network of microscopic steps, including the primary nucleation of monomers into misfolded oligomers, the conversion of these oligomers into more ordered growth-competent species, the elongation of fibrils, and the secondary nucleation of monomers in a fibril-catalyzed manner (Michaels et al., 2020