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Doses below 200mcg may not produce sufficient GH pulse amplitude to drive metabolic changes, while doses above 500mcg dont appear to increase response magnitude based on clinical trial data

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GLP-1RAs promote glucose uptake in the skeletal muscle by increasing microvascular blood flow and tissue perfusion and inhibit muscle catabolism via the AMP-activated protein kinase pathway [39, 77, 83]

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The authors would like to thank the Roger de Spoelberch Foundation for funding the electron microscopy platform (LCSB/LNS)