Tirzepatide is a glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor dual agonist
Very rare: hypersensitivity reaction
Long-term human safety data remains limited
A 2026 narrative review in Clinical Obesity by Urbina and colleagues, which pooled six studies covering 480,825 adults, found that more than 60% of GLP-1 users consumed below estimated requirements for calcium and iron, and that average vitamin D intake landed at just 20% of recommendations (PubMed: 41549912)
The most common concentrations from compounding pharmacies include 1 mg/mL, 2 mg/mL, 2.5 mg/mL, 3 mg/mL, 5 mg/mL, and 10 mg/mL
Ask if you will need prior authorization, and what is required for the medication to be covered