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GPX4, a selenoprotein enzyme, is vital for protecting cells against oxidative stress by reducing lipid hydroperoxides and inhibiting lipid peroxidation

LL-37 serves as an antimicrobial peptide naturally occurring in the human body

Current DAMP/PRR-targeted therapeutic strategies are comprehensively reviewed, including: modulating cell death pathways to reduce DAMP release, neutralizing DAMP activity using monoclonal antibodies, developing small-molecule inhibitors to block signaling pathways, and employing enzymatic degradation or gene silencing technologies for precise intervention

Morpheus 8 outcomes: 12 to 18 months with annual maintenance