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Prospective trials are needed to determine whether GLP-1 receptor agonists can be repurposed as gerotherapeutics

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This supports a model in which CHAC1-mediated GSH depletion destabilizes NRF2 and reduces cystine import, allowing iron-dependent lipid peroxides to accumulate and trigger ferroptosis

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Lagan M, Piticchio T, Alibrandi A, Le Moli R, Pallotti F, Campenn A et al (2025) Effects of Dietary Habits on Markers of Oxidative Stress in Subjects with Hashimotos Thyroiditis: Comparison Between the Mediterranean Diet and a Gluten-Free Diet