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MTHFR and COMT mutations can reduce methylation activity and result in the accumulation of harmful estrogens

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Furthermore, the putative molecules effective in disrupting the FMRP-CYFIP1-eIF4E or eIF4E-eIF4G complexes formation, are required to target protein-protein interaction (PPI) interfaces, that are large, flat and hydrophobic binding surfaces considered as undruggable by small compounds (118120)

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Fibroblasts also appear to secrete various biological substances, including the Vascular Endothelial Growth Factor (VEGF), which is suggested to promote the formation of new blood vessels