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Peroxidation of the lipid membrane under the action of hydroxyl radical has the effect of disrupting the calcium transport within the endoplasmic reticulum, decreasing its uptake and increasing its level in myocytes during dystole (4,5), leading to dysrhythmias

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doi: 10.1038/s41392-023-01400-z, 31

In the primary analysis, participants remained classified according to the drug they initially received, regardless of discontinuation or switching