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Improving insulin sensitivity can also help manage high blood pressure, reducing the risk of heart disease

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*GIP= glucose-dependent insulinotropic polypeptide / ** FDA approved age for weight loss indication*GIP= glucose-dependent insulinotropic polypeptide Efficacy Comparison While the GLP-1s agents in the table below were not evaluated in head-to-head clinical trials, their studies were conducted over similar durations (6472 weeks) and enrolled comparable patient populations, allowing for cross-trial comparisons

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placebo ranged from -8.8% (95% CI -10.3, -6.3) to -6.9% (95% CI -9.1, -4.7) from no diuretics to the highest loop diuretic dose category