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In the case of glutathione, its bioavailability when taken orally has been questioned due to the following factors: Gastrointestinal Degradation : Glutathione is susceptible to degradation in the gastrointestinal tract due to the presence of various enzymes

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Shen Z, Wu W, Hazen SL: Activated leukocytes oxidatively damage DNA, RNA, and the nucleotide pool through halide-dependent formation of hydroxyl radical

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They reported that skeletal muscle contains sialin ( transporter) and xanthine oxidoreductase and stated that skeletal muscle also plays an main role in the transport, storage, and metabolism of the