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This imbalance may be a precursor to multiple diseases including cancer, diabetes, and rheumatoid arthritis

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Both increased production of ROS and lowered anti-oxidant defense, resulting in impaired oxidant/anti-oxidant balance 39

In vivo (31) P MRS assessment of intracellular NAD metabolites and NAD(+) /NADH redox state in human brain at 4 T

PQQ (Pyrroloquinoline Quinone) completes the cellular energy triangle through its remarkable ability to stimulate mitochondrial biogenesis -- the creation of new mitochondria