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Two independent reviewers (WM and LB) searched the electronic PubMed/MEDLINE, Scielo, Embase and Cochrane Controlled Trials databases using the terms semaglutide or GLP-1RAs combined with acute pancreatitis or gastrointestinal adverse effects or pancreatic adverse effects and extracted data

The cagrilintide and semaglutide combination leverages two distinct satiety pathways (amylin and GLP-1) for enhanced appetite suppression and weight loss beyond what either compound achieves alone

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