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Src-homology 2 domain-containing phosphatase 2 (SHP2) is essential for full KRAS activity, and promising dual SHP2/mitogen-activated protein kinase (MAPK) inhibition is currently being tested in clinical trials

El Frargy, M., El-Sharkawy, H

Dai EL, Han J, Liu, et al

Sadeghi R et al

Project 1 was the joint work of Farrah Sadre-Marandi (consultant at qPharmetrica), Thabat Dahdoul (graduate student at UC Irvine), Michael Reed, and Fred Nijhout and appeared in paper

Its incidence is relatively low, but only a part of patients could survive for more than 1 month, and most of them suffer from disability (van Asch et al., 2010), which contribute to the high mortality of ICH