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Clinical trials found the average weight loss as follows: 4 weeks: ~2% of the starting weight 8 weeks: ~4% 12 weeks: ~6% 16 weeks: ~8% 20 weeks: ~10% 28 weeks: ~12% 36 weeks: ~14% 52 to 60 weeks: ~15% 68 weeks: ~15.6% For example, if your starting weight is 232 lbs, you can expect to lose about 15% of your total body weight (35 lbs of excess weight) after 68 weeks (15 months) on Wegovy

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Mitochondria and reactive oxygen species

Its also prescribed off-label for reducing body weight combined with diet and exercise

This spike and crash effect can make you feel hungrier, more tired, and less satisfied after eating