The lower bioavailability actually works in favor here, as the body receives the active compound more gradually throughout the day rather than in a single bolus that can overwhelm GLP-1 receptors in the gut
Here's some of the main functions of glutathione: When you drink alcohol, it can deplete the body of glutathione, the potent antioxidant that helps rid the body of toxic substances and make you more susceptible to oxidative stress
Metsera has a nice slide on this below, and assuming their calculations are true, this COGs delta could prove to be a valuable commercial advantage
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[85] attempted to determine whether stapling can generate alternative GLP-1 therapeutic candidate drugs through the use of simplified validation workflows and stapling design