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Here are some general guidelines: Mild deficiency: The typical treatment is a 250-500 mcg liquid B12 dose prescribed to patients with the mildest B12 deficiency

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Start at 0.25mg daily for at least one week before considering any increase

Hooijberg JH, Pinedo HM, Vrasdonk C, Priebe W, Lankelma J, Broxterman HJ