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A Cochrane systematic review of randomized trials for melasma found combination therapy more effective than single agents (a Cochrane systematic review of randomized trials for melasma), and a study in Middle Eastern skin confirmed a tretinoin and hydroquinone combination was effective and tolerated in deeper skin tones (a study of a hydroquinone and tretinoin combination for melasma in deeper skin tones)

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Melanoma metastases are highly dependent on the SSP in nutrient-limited environments, and PHGDH knockout or inhibition markedly suppresses the metastatic capacity of melanoma in mouse models (88)

Yes its defining property is stability in gastric juice, where most growth-factor peptides break down within minutes [1]