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In 2019, the American Diabetes Association/European Association for the Study of Diabetes published an updated consensus report on the treatment of hyperglycemia recommending GLP-1 receptor agonist inhibitors as agents of choice in patients with established cardiovascular disease and especially in those with specific indicators of high cardiovascular risk [5]

doi: 10.1053/j.gastro.2009.02.050

In the 1900s, Karl Herxheimer noted a similar reaction

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These symptoms frequently manifest during the initial treatment phase, affecting approximately 50% to 60% of patients [8], but they generally diminish over time, with their occurrence being dose-dependent