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The complete complex was expressed from the multi-expression construct described above for structure determination, containing Twin-Strep-tagged CDK11B p58 , His 6 -tagged Cyclin L2 (1319), and MBP-tagged SAP30BP
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While the road ahead may be challenging, the potential benefits make the exploration of 5-Amino-1MQ a journey well worth taking in the pursuit of increased longevity