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At precisely the times indicated, 10 L of the radioactive dose (typically 0.25 Ci) was spiked into each tube to bring the final volume to 200 mL

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Among 21,822 people of European ancestry, we required participants to have complete data needed to construct the target phenotype and GWAS covariates (that is, data available for pre-treatment weight, post-treatment weight, drug type, dosage, time on treatment and factors such as age, sex and height), resulting in 18,488 participants