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Changes in oxygen consumption (energy expenditure) during food restriction were then reported as percentage of the values obtained from baseline (typically 2 to 3 days of recordings before food restriction)

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Eat slowly, drink 23 liters of water daily, and avoid liquid calories, which bypass satiety signals entirely

In clinical protocols it is administered as a slow 2 to 6 hour infusion to maintain target plasma levels

Notably, volunteers receiving 9 and 12 mg doses reported decreases in appetite, however, severe nausea and vomiting as well as increased erections were also reported in these cohorts

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