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To a large extent, this tolerance development can be compensated for by gradually titrating the medication dose upwards, usually by adding a second dose in the early afternoon to provide reasonable all-day appetite control

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Turkish J Forecast 7(2):1016 Flohe L, Gunzler WA, Schock HH (1973) Glutathione peroxidase: a selenoenzyme

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Guo P, Deng Y