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Break-induced telomere synthesis underlies alternative telomere maintenance

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Although treatment is associated with short-term side effects, such as decreased appetite [46], weight loss, headaches, anxiety [13,46], and sleep problems [47], it also has long-term effects, such as impacting bone health [46,48]

Rushing the escalation is the single most common mistake that leads to severe gastrointestinal side effects and treatment discontinuation

10.1097/00000421-199406000-00006 11 BrerA.FairweatherS.BrerS

This dose intensification may enhance local control, particularly in bulky or hypoxic cervical cancers where organ constraints limit conventional brachytherapy