Allergic reactions , whilst rare, can occur and range from mild skin reactions to severe anaphylaxis
Similarly, pairing peptides with strong exfoliants or high percentages of active ingredients may lead to irritation or counteract their benefits
So the two papers above are doing real scientific work
NNMT inhibition reduces consumption of nicotinamide (and of S-adenosylmethionine) by blocking the enzyme that would otherwise methylate them
Common research protocols cited in the peptide community use 1 to 2 mg, 3 to 5 times weekly, over 8 to 12-week cycles
It works by inhibiting NNMT, leading to metabolic changes that can promote the use of fat for energy, reduce fat storage, and potentially slow down cellular aging