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[30] At the injection site, its possible to have some redness, swelling, or irritation

Necrosis, necroptosis, and pyroptosis, inflammatory cell death modalities Unlike the controlled, typically non-inflammatory process of apoptosis, necrotic and necroptotic cell death are characterized by plasma membrane integrity loss, resulting in the extracellular release of intracellular components, including intact mitochondria or mitochondrial fragments that harbor mtDNA [85, 86]

2019) (Tables 3, 4)

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Combination therapy with PI3K and MEK inhibitors inhibited histone Kla (H3K18la) in TAMs and controlled tumor growth in 80% of PTEN/p53-deficient prostate cancer mice