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Development of a novel strategy for robust synthetic bacterial promoters based on a stepwise evolution targeting the spacer region of the core promoter in Bacillus subtilis

Key Takeaways GLP-1 receptor agonists (GLP-1 RAs)including semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound)cause weight loss primarily by suppressing appetite, which can lead to a caloric deficit deep enough to trigger lean body mass (LBM) loss alongside fat loss

L-carnitine may also support exercise recovery by helping to mitigate exercise-induced oxidative stress due to its antioxidant activity [13,14].* Supports Cardiovascular Health L-carnitine has been shown to support healthy cardiovascular function [15]

Attenuation of oxidative stress could be a promising strategy to diminish storage lesions

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A potent therapeutic scaffold fusing quinazolinone/melatonin for future colorectal cancer interventions: design, one-pot synthesis, biological and ADME-tox modeling studies