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Data on different cell types indicate that this MDP attenuates ROS-mediated oxidative damage (e.g., The ability to attenuate oxidative stress and the subsequent inflammatory response has been also reported for MOTS-c (e.g., The dual mitochondrial/nuclear localization is also shown for SHLP 2 and 3, whereas SHLP 1, 4, 5, and 6 are located exclusively in the mitochondria ( MDPs are known to act as both paracrine and endocrine signaling molecules (e.g., 3.2 Mitochondria-derived vesicles It is well known that cells secrete mitochondrial proteins, mtDNA, and even intact mitochondria as part of mitochondrial quality control (e.g., Upon oxidative mitochondrial damage, a greater number of MDVs are targeted to lysosomes for degradation, which in turn blocks the secretion of mitochondrial content by EVs ( It appears that MDVs and EVs could be addressed clinically, although more research is required to fully use the diagnostic and therapeutic potential of MDVs

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Once that patent expires, other companies may be able to produce generic forms, which could help bring prices down and make these medications more accessible