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Retatrutide Side Effects In clinical trials, the most common side effects observed in patients treated with these medications were nausea, low blood sugar, diarrhea, constipation, vomiting, headache, decreased appetite, upset stomach, fatigue, dizziness, and abdominal pain

The approved-pathway comparison points remain tirzepatide (Mounjaro/Zepbound) on its own and the investigational CagriSema (cagrilintide + semaglutide)

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For patients who feel hungry soon after meals or struggle with late-night cravings, this effect can be a major advantage in building healthier eating patterns