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Bromelain induced a reduction in cell proliferation of 72.6% (at 1.25 g/mL) and 66.5% (at 0.625 g/mL) at 24h in MCF-7 cells, however in this case bromelain was mobilized in nanocapsules surface by coordination with Zn +2 facilitating the entry into the cell (75)

[6] Geng L, Lam KSL, Xu A

It must be emphasized that there are exceptions to each criterion, and the failure to consider this may result in both over- and underdiagnosis of melanoma