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Unlike native IGF-1, which requires frequent administration due to its short half-life and extensive IGFBP binding, IGF-1 LR3's enhanced stability and bioavailability make it a more practical candidate for investigating growth factor-mediated tissue regeneration and metabolic regulation

Results vary significantly based on individual skin type, formulation quality, and adherence to application protocols

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These effects were attributed to activation of Nrf2 by SFN