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A meta-analysis conducted by Chen et al., consisting of 13 controlled clinical trials with 3512 participants, showed better efficacy of tailored therapies compared with empirically chosen regimens (Chen et al

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Angiotensin IV (Val 1 -Tyr 2 -Ile 3 -His 4 -Pro 5 -Phe 6 ) is an endogenous hexapeptide fragment of the renin-angiotensin system, historically considered a metabolite of angiotensin II but subsequently shown to have independent procognitive activity in rodent models

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Chen et al., 2023a