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doi: 10.1007/s11010-013-1637-3 212 WangZ.LuoW.WangQ.LiuC.GongY.LiB.et al

That difference in mechanism is one of the main reasons doctors consider them separately rather than treating them as interchangeable options for every patient

Therefore, to determine the specificity of the complete loss of H3K27me3 expression in the context of the differential diagnosis of malignant peripheral nerve sheath tumor from melanoma (its major potential mimic), we performed H3K27me3 immunohistochemistry in a pathologically and genetically well-characterized cohort of primary (neurofibromatosis type 1 (NF1), radiation-associated and sporadic context) malignant peripheral nerve sheath tumors ( n =122) and in a cohort or primary (desmoplastic) and metastatic melanomas ( n =265)

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