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In summary, GLP-1RA therapy is clearly associated with a substantially increased risk of retained gastric contents, but there is little evidence to suggest that this translates to an increased incidence of aspiration pneumonia

Side effects can persist after a dose change Because GLP1 levels taper gradually rather than dropping to zero, symptoms can continue for days or even weeks after a dose change

This leads to lower calorie consumption and better control over eating habits

doi: 10.1136/bcr-2020-235663

Natural GLP-1 supplements like Thrive take a completely different approach