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total GSH: GSSG+2GSH) maintained at 89 8% of untreated control with GHK-Cu+HO versus 62 7% HO alone

Further research is needed to elucidate the precise mechanisms through which GLP-1R agonists exert their benefits and to establish their long-term safety and efficacy in diverse HFpEF populations

NG, AT, and MB were involved in the critical revision and writing of the manuscript

Montandon SA, Jornayvaz FR (2017) Effects of Antidiabetic Drugs on Gut Microbiota Composition

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GCLC also exerts a non-canonical, GSH-independent protective function by maintaining glutamate homeostasis during cystine starvation 145