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Cellular senescence is closely linked to fibrosis, as demonstrated by nonproliferative, p16-positive myofibroblasts in fibrotic lung tissues [15]

Control of satellite cell function in muscle regeneration and its disruption in ageing

Mechanisms of Collagen Synthesis The collagen synthesis mechanisms involve several key pathways: MAPK/ERK Pathway Activation This pathway upregulates collagen gene expression and promotes fibroblast proliferation, creating the cellular foundation for tissue repair