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Using biochemical assays, kinetic analysis, and molecular docking studies, we demonstrated that the dimer form exhibits superior binding affinity and inhibitory potency compared to both the monomer form and the reference inhibitor, ethacrynic acid

Collectively, these findings begin to reveal the genetic networks that regulate progenitor fitness and demonstrate the potential of epithelioid cultures for such studies

It also improved the proliferative and secretory functions of fibroblasts and reversed morphological abnormalities of senescent cells (such as flattened cell shape, enlarged volume, and nuclear pyknosis)

10.3389/fendo.2022.1000094 50 NittaC

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