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Participants had normal vital signs, 12-lead electrocardiogram results and clinical laboratory tests at the time of randomization

Holst completed a doctorate in medical sciences at the University of Copenhagen in 1978 where he was subsequently appointed professor of physiology

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The data regarding the participants demographic, clinical and therapeutic characteristics, outcomes and other important parameters were extracted from tabular, textual and graphic sources of the published research papers independently by two researchers and were cross-checked later (kappa = 0.95)