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Moreover, p53-regulated CDKN1A/p21 expression attenuated ferroptosis by promoting the generation of cellular GSH (Fig

Evidence suggests that GLP-1 pathways influence the central nervous system via multiple routes: some agents and/or their downstream effects reach or affect the brain and bloodbrain barrier , altering glucose transport, microglial activation, and synaptic function in preclinical and early human studies

As AUD is a heterogeneous disorder with a multifaceted pathophysiology, the possibility that combinations of GLP-1 and other gutbrain axis peptides synergistically reduce alcohol drinking should be explored in future studies

Eur J Endocrinol 178:365375 Takai M, Izumino K, Oda Y, Terada Y, Inoue H, Takata M (2001) Focal segmental glomerulosclerosis associated with acromegaly

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