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In the setting of gut-derived neuroinflammation, ISR activation robustly promoted transcription of LD biogenesis genes, leading to excessive neutral-lipid accumulation in microglia, whereas pharmacological ISR blockade (with ISRIB) largely reversed the LD burden evoked by inflammatory stimuli, confirming the causal role of ISR in lipotoxic injury

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OPRAH JOINS WAVE OF CELEBRITIES WHO REVEALED DRAMATIC WEIGHT LOSS IN 2025 "Consumers worldwide continue to seek quality and moments of indulgence," Lechner said in a news release