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Because these are distinct satiety circuits, the hypothesis is that combining them could produce additive appetite suppression rather than simply doubling a single mechanism

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Additionally, paeoniflorin was reported to reduce the expression of the L-tryptophan-catabolizing enzyme tryptophan-2,3-dioxygenase in the liver of stress-induced depressive mice, thereby increasing the 5-hydroxytryptamine/tryptophan ratio and decreasing the kynurenine/tryptophan ratio (Liang et al., 2023)

Macular and papular areas (fried egg appearance) may be present within a single lesion

neuroinflammation 17, 416

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