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Metabolic and Endocrinology Surgery Unit Unidad de Ciruga Endocrina y Metablica (UCEM) This reduction in angiotensin II levels follows the administration of GLP-1 possibly results from the increase in blood pressure values, the increased delivery of sodium to the macula densa and the reduced activity of tissue reninangiotensin-aldosterone system

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Overall, autonomic imbalances caused by obesity may be associated with the first occurrence of ferroptosis in the vagus nerve, which impairs its ability to transmit information collected by the sensory nerve to the nerve center, as well as its ability to mobilize GSH and NO to prevent ferroptosis

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doi: 10.1038/s41577-020-0407-1 157 LageS