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A calorie calculator can provide a useful starting estimate, but your average body weight trend is the best way to refine that target

Clinical assessments were conducted every 3 months to evaluate efficacy, measured as percentage of total weight loss (%TWL), excess weight loss (%EWL), changes in BMI, and improvement in comorbidities, as well as tolerance, monitored for adverse effects including gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea) and discontinuation rates

Diabetes Obes Metab (2015) 17:66574

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Your IV nutrition therapy training should clarify these regulatory pathways