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Overall, sulfur-containing amino acid metabolism can be more appropriately viewed as an integrated module of methylation potential and redox homeostasis: the Met-SAM axis is mainly associated with the plasticity of epigenetic and transcriptional programs, the Cys-GSH/H 2 S axis primarily influences oxidative stress and the threshold of inflammatory signaling, and Tau is further linked to antioxidation and the regulation of mitochondrial homeostasis