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Intestinal microbiota plays a key role in maintaining the homeostasis of the digestive tract, limiting the colonization of pathogens, and regulating metabolism [10,11,12]

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Thus, whereas the currently available short-acting GLP-1 analogues have plasma half-lives of ~34 h, future compounds exhibiting half-lives of ~12 h may exploit the mechanism of delaying gastric emptying even more specifically

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