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Common Side Effects and Management As with any medication, semaglutide can cause side effects

Your prescribing provider may adjust your injection schedule, reduce dose temporarily, or switch to oral semaglutide formulation to mitigate side effects while maintaining therapeutic progress

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Increases local concentration while reducing systemic exposure

Lancet 2017;390:2347-59.PubMedPMC 203

The proposed mechanism is telogen effluvium: a temporary shedding phase triggered by the physiologic stress of rapid weight loss and significant caloric restriction, rather than a direct toxic effect of the drug on hair follicles