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598 FTH1 knockdown in neurons significantly inhibits cell viability and causes mitochondrial dysfunction, while overexpression of FTH1 impairs ferritinophagy, downregulates the expression of LC3 and NCOA4, and finally inhibits cell ferroptosis

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Officially mandated by legislative action, the programme has screened all babies born in Tuscany since November 2004 (35 000 per year) and all babies born in Umbria since 2010 (7500 per year) for selected acyl-carnitines and amino acids