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Tissues and structures affected by knee OA include: The articular cartilage, a smooth surface covering the bones that reduces friction and serves as a shock absorber gradually breaks down and erodes

TB 500 then facilitates cellular mechanics, promoting the migration of repair cells (endothelial cells, fibroblasts, myocytes) to the injury site via actin dynamics

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PMID: 35013352

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Prior to the study of these targeted compounds, gastrointestinal inflammation research relied largely on broad anti-inflammatory agents and nonspecific interventions