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For example, at least 70 percent of participants in National Institute of Environmental Health Sciencessupported trials were females in all years for which data are reported, but the share of females was less than 40.5 percent in trials supported by the National Institute on Aging in 2017 and 2018 (this may be of particular concern in indications such as Alzheimers disease and other dementias where female prevalence exceeds that of males)