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Naslund et al., 1999

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PIONEER 3: Head-to-head vs Januvia (sitagliptin) 1,4 Study design: 78-week, randomized, double-blind, double-dummy, active controlled, parallel-group, phase 3a trial designed to assess the efficacy and assess long-term adverse event profile of once-daily semaglutide tablets vs Januvia in addition to metformin with or without sulfonylurea

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In insulin-resistant cell models, SHBG expression is downregulated, which leads to increased GLUT1 expression along with decreased GLUT3 and GLUT4 levels [234]